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KMID : 0615720150320010053
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Jouranl of Korean Acupuncture and Moxibustion society
2015 Volume.32 No. 1 p.53 ~ p.66
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Effects of Curculiginis Rhizoma Pharmaco-Acupuncture at ST36 on Monosodium Iodoacetate(MIA)-induced Osteoarthritic Rats
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Ji Min-Jung
Lim Seong-Chul
Kim Jae-Soo
Lee Hyun-Jong
Lee Yun-Kyu
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Abstract
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Objectives: This study was designed to investigate effects of Curculiginis Rhizoma pharmaco- acupuncture at ST36 on monosodium iodoacetate-induced osteoarthritic rats.
Methods: Twenty rats were divided into four groups consisting of 5 rats: rats receiving no injection(normal), rats injected with monosodium Iodoacetate(MIA, control), rats injected with MIA and normal saline(N-S), and rats injected with MIA and Curculiginis Rhizoma (CRPA). N-S and CRPA were administered once a day at ST36 during 21 days. After that we examined the weight-bearing ability of hind paws, liver and kidney function, immunocell, cytokines, proteins, and gene expression of cytokines. Injury of synovial tissue was measured by H & E, Safranin O immunofluorescence.
Results: The weight-bearing ability of the hind paws, Serum TNF-α, IL-1β, IL-6, PGE2, LTB4, DPD, Osteocalcin, Protein COX-2 of CRPA decreased significantly. Protein Arachidonate 5 li- poxygenase of CRPA was decreased, but not significantly. Expression of gene COX-2, TNF-α, IL-1β, IL-6, NOS2 of CRPA decreased. In histological observations, CRPA was improved, compared with other control groups.
Conclusions: It can be suggested that Curculiginis Rhizoma pharmaco-acupuncture at ST36 has anti-inflammatory and pain relief effects on monosodium iodoacetate-induced osteoarthritic rats.
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KEYWORD
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Curculiginis Rhizoma pharmaco-acupuncture, Osteoarthritis, Monosodium iodoacetate(MIA), ST36
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